Details

Autor(en) / Beteiligte

• Valassi, Elena
• Santos, Alicia
• Yaneva, Maria
• Tóth, Miklós
• Strasburger, Christian J
• Chanson, Philippe
• Wass, John A H
• Chabre, Olivier
• Pfeifer, Marija
• Feelders, Richard A
• Tsagarakis, Stylianos
• Trainer, Peter J
• Franz, Holger
• Zopf, Kathrin
• Zacharieva, Sabina
• Lamberts, Steven W J
• Tabarin, Antoine
• Webb, Susan M

Titel

The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics

Ist Teil von

• European journal of endocrinology, 2011-09, Vol.165 (3), p.383

Ort / Verlag

England

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The European Registry on Cushing's syndrome (ERCUSYN) is designed to collect prospective and follow-up data at EU level on Cushing's syndrome (CS). Baseline data on 481 CS patients (390 females, 91 males; mean age (±s.d.): 44±14 years) collected from 36 centres in 23 countries, including new patients from 2008 and retrospective cases since 2000. Patients were divided into four major aetiologic groups: pituitary-dependent CS (PIT-CS) (66%), adrenal-dependent CS (ADR-CS) (27%), CS from an ectopic source (ECT-CS) (5%) and CS from other aetiologies (2%). Proportion of men in the ECT-CS group was higher than in the other groups (P<0.05). The ADR-CS group was older than the PIT-CS (P<0.05). Prevalence of hirsutism (92%) and diabetes (74%) in ECT-CS was higher than in the other groups (P<0.05 and P<0.01 respectively). PIT-CS had more skin alterations, menstrual irregularities and hirsutism than ADR-CS (P<0.01). Reduced libido was more prevalent in men than women (P<0.01). Prevalence of spine osteoporosis was higher in men than women (P<0.05), and males had more vertebral and rib fractures than females (52 vs 18% for vertebrae; P<0.001 and 34 vs 23% for ribs; P<0.05). ECT-CS consulted a diabetologist more frequently than ADR-CS (P<0.05), while a gynaecologist was consulted more often by women with PIT-CS or ADR-CS than with ECT-CS (P<0.05). Overall, weight gain was more common in women than men (P<0.01). CushingQoL and EuroQoL visual analogue scale scores did not differ between the groups. The ERCUSYN project demonstrates a heterogeneous clinical presentation of CS at a European level, depending on gender and aetiology.