Antimicrobial Agents and Chemotherapy, 2011-09, Vol.55 (9), p.4465-4468
2011
Details
- Autor(en) / Beteiligte
- Titel
- Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene
- Ist Teil von
- Antimicrobial Agents and Chemotherapy, 2011-09, Vol.55 (9), p.4465-4468
- Ort / Verlag
- Washington, DC: American Society for Microbiology
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more triazoles, all originating in China, contained the TR/L98H mutation associated with resistant European isolates of A. fumigatus. This is the first time the TR/L98H mutation has been identified outside Europe.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4804eISSN: 1098-6596DOI: 10.1128/AAC.00185-11Titel-ID: cdi_pubmed_primary_21690285
- Format
- –
- Schlagworte
- Antibiotics. Antiinfectious agents. Antiparasitic agents, Antifungal Agents, Antifungal Agents - pharmacology, Aspergillus fumigatus, Aspergillus fumigatus - drug effects, Aspergillus fumigatus - genetics, Biological and medical sciences, Cytochrome P-450 Enzyme System, Cytochrome P-450 Enzyme System - genetics, drug resistance, Drug Resistance, Fungal - genetics, Fungal Proteins, Fungal Proteins - genetics, genes, itraconazole, Itraconazole - pharmacology, Mechanisms of Resistance, Medical sciences, Microbial Sensitivity Tests, minimum inhibitory concentration, monitoring, Mutation, nucleotide sequences, Pharmacology. Drug treatments, provenance