Zhonghua shi yan he lin chuang bing du xue za ji, 2010-12, Vol.24 (6), p.412
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Study on characteristics of cellular-mediated immune responses of novel H1N1 influenza A patients with pneumonia
- Ist Teil von
- Zhonghua shi yan he lin chuang bing du xue za ji, 2010-12, Vol.24 (6), p.412
- Ort / Verlag
- China
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the phenotype, frequency and function of CD4+ T cell subsets and the relevant cytokines, as well as the relationship between these cells and appearance of pneumonia of novel (H1N1) influenza A patients. 68 healthy people, 53 confirmed novel A(H1N1) influenza patients without pneumonia and 16 confirmed severe novel A (H1N1) influenza patients with pneumonia were enrolled in this study. Viral load in nasopharyngeal swabs specimens was measured by real time PCR assay. The phenotype and percentage of CD4+ T cell subsets including Th1, Th2, Th17, and Treg cells were measured by Flow cytometry analysis. The relevant cytokines in plasma including TGF-beta, IL-6 and IFN-gamma were measured by ELISA. Data was analyzed by one way ANOVA. It was found that peak viral load and viral shedding period of severe patients with pneumonia was significantly increased compared with mild patients without pneumonia (P < 0.05). The percentage of Th17 cells of severe patients with pneumonia was significantly diminished
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1003-9279Titel-ID: cdi_pubmed_primary_21604561