Nature immunology, 2011-06, Vol.12 (6), p.568
2011
Details
- Autor(en) / Beteiligte
- Titel
- The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
- Ist Teil von
- Nature immunology, 2011-06, Vol.12 (6), p.568
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) require exposure to IL-23 to become encephalitogenic, but the mechanism by which IL-23 promotes their pathogenicity is not known. Here we found that IL-23 induced production of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in T(H)17 cells and that GM-CSF had an essential role in their encephalitogenicity. Our findings identify a chief mechanism that underlies the important role of IL-23 in autoimmune diseases. IL-23 induced a positive feedback loop whereby GM-CSF secreted by T(H)17 cells stimulated the production of IL-23 by antigen-presenting cells. Such cross-regulation of IL-23 and GM-CSF explains the similar pattern of resistance to autoimmunity when either of the two cytokines is absent and identifies T(H)17 cells as a crucial source of GM-CSF in autoimmune inflammation.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1529-2916DOI: 10.1038/ni.2031Titel-ID: cdi_pubmed_primary_21516111
- Format
- –
- Schlagworte
- Animals, Antibodies - immunology, Antibodies - pharmacology, CD11c Antigen - immunology, CD11c Antigen - metabolism, CD4-Positive T-Lymphocytes - drug effects, CD4-Positive T-Lymphocytes - immunology, CD4-Positive T-Lymphocytes - metabolism, Cells, Cultured, Coculture Techniques, Encephalomyelitis, Autoimmune, Experimental - chemically induced, Encephalomyelitis, Autoimmune, Experimental - immunology, Encephalomyelitis, Autoimmune, Experimental - metabolism, Female, Flow Cytometry, Glycoproteins, Granulocyte-Macrophage Colony-Stimulating Factor - genetics, Granulocyte-Macrophage Colony-Stimulating Factor - immunology, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism, Interleukin-1 - pharmacology, Interleukin-1beta - pharmacology, Interleukin-23 - immunology, Interleukin-23 - metabolism, Interleukin-23 - pharmacology, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Myelin-Oligodendrocyte Glycoprotein, Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics, Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology, Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism, Peptide Fragments, Th1 Cells - drug effects, Th1 Cells - immunology, Th1 Cells - metabolism, Th17 Cells - drug effects, Th17 Cells - immunology, Th17 Cells - metabolism, Transforming Growth Factor beta - pharmacology