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The purpose of the investigation was to evaluate changes in the functional activity of the vascular endothelium (by the levels of adhesion molecules) and in blood hemostatic function (plasma hemostasis, thromboelastography) in 70 patients with coxarthrosis before and after endoprosthetic hip joint replacement. The blood coagulation system was normal in the patients prior to the surgery. According to the content of adhesion molecules, there were two groups of patients: 1) those with their normal levels and 2) those with their elevated ones. Following the surgery, all the patients developed a hypercoagulation reaction in the blood coagulation system. In the patients with the normal baseline level of adhesion molecules, the latter were higher after endoprosthetic replacement and in those with their elevated baseline levels, the latter were lower.