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Computer simulation on disease vector population replacement driven by the maternal effect dominant embryonic arrest
Ist Teil von
Advances in experimental medicine and biology, 2011, Vol.696, p.335
Ort / Verlag
United States
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In this chapter, we present a series of computer simulations on the genetic modification of disease vectors. We compared the effectiveness of two techniques of genetic modification, transposable elements and maternal effect dominant embryonic arrest (MEDEA). A gene drive mechanism based on MEDEA is introduced in the population to confer immunity to individuals. Experimental results suggested that the genetic maternal effects could be necessary for the effectiveness of a disease control strategy based on the genetic modification of vectors.