Details

Autor(en) / Beteiligte

• Díaz Negrillo, A
• Martín Del Valle, F
• González Salaices, M
• Prieto Jurczynska, C
• Carneado Ruiz, J

Titel

Levetiracetam efficacy in patients with Lennox-Gastaut syndrome. Presentation of a case

Ist Teil von

• Neurologia (Barcelona, Spain), 2011-06, Vol.26 (5), p.285

Ort / Verlag

Spain

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies of childhood, characterized by electro-clinical triad of generalized spike-wave activity, slow (POL) in the electroencephalogram (EEG), multiple types of seizures and development delay. This paper intends to describe the syndrome in a patient with a history of hypoxic-ischaemic encephalopathy and Lennox-Gastaut syndrome, and a good response to treatment with levetiracetam (LEV). Descriptive study on the development of a 3 year old child with intrauterine asphyxia, multiorgan failure, metabolic acidosis, hypovolemic shock, and seizures with cerebral oedema, who developed a West syndrome, resistant to drug treatment. The semiology of seizures progressively changed to generalized episodes of hypertonia and myoclonus, with slow spike-wave electroencephalographic activity. With the diagnosis of Lennox-Gastaut syndrome the patient was treated with levetiracetam, showing a substantial improvement in the cognitive sphere, in the control of seizures, and electroencephalographic findings. Lennox-Gastaut syndrome is one of the most severe epileptic syndromes in paediatric patients. Levetiracetam can help cognitive improvement, and contribute to seizure control in these patients.