Nature reviews. Immunology, 2011-03, Vol.11 (3), p.176-186
2011
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- DCs and NK cells: critical effectors in the immune response to HIV-1
- Ist Teil von
- Nature reviews. Immunology, 2011-03, Vol.11 (3), p.176-186
- Ort / Verlag
- England
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Dendritic cells (DCs) and natural killer (NK) cells have central roles in antiviral immunity by shaping the quality of the adaptive immune response to viruses and by mediating direct antiviral activity. HIV-1 infection is characterized by a severe dysregulation of the antiviral immune response that starts during early infection. This Review describes recent insights into how HIV-1 infection affects DC and NK cell function, and the roles of these innate immune cells in HIV-1 pathogenesis. The importance of understanding DC and NK cell crosstalk during HIV infection for the development of effective antiviral strategies is also discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1474-1733eISSN: 1474-1741DOI: 10.1038/nri2935Titel-ID: cdi_pubmed_primary_21350578
- Format
- –
- Schlagworte
- Adaptive Immunity - immunology, AIDS Vaccines - immunology, Animals, Antigen Presentation, Antigens, CD - metabolism, Autophagy, Cell Adhesion Molecules - metabolism, Cell Communication, Dendritic Cells - immunology, Dendritic Cells - virology, Female, Haplorhini, HIV Antigens - immunology, HIV Envelope Protein gp120 - metabolism, HIV Infections - immunology, HIV-1 - immunology, Humans, Killer Cells, Natural - immunology, Lectins, C-Type - metabolism, Male, Mannose-Binding Lectins - metabolism, Receptors, Cell Surface - metabolism, Receptors, HIV - immunology, Receptors, HIV - physiology, Receptors, KIR - immunology, Simian Acquired Immunodeficiency Syndrome - immunology, Simian Immunodeficiency Virus - immunology, Toll-Like Receptor 8 - metabolism, Vaccination