Neurology, 2011-02, Vol.76 (5), p.475
2011
Details
- Autor(en) / Beteiligte
- Titel
- An algorithm for genetic testing of frontotemporal lobar degeneration
- Ist Teil von
- Neurology, 2011-02, Vol.76 (5), p.475
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To derive an algorithm for genetic testing of patients with frontotemporal lobar degeneration (FTLD). A literature search was performed to review the clinical and pathologic phenotypes and family history associated with each FTLD gene. Based on the literature review, an algorithm was developed to allow clinicians to use the clinical and neuroimaging phenotypes of the patient and the family history and autopsy information to decide whether or not genetic testing is warranted, and if so, the order for appropriate tests. Recent findings in genetics, pathology, and imaging allow clinicians to use the clinical presentation of the patient with FTLD to inform genetic testing decisions.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1526-632XDOI: 10.1212/wnl.0b013e31820a0d13Titel-ID: cdi_pubmed_primary_21282594
- Format
- –
- Schlagworte
- Adult, Aged, Algorithms, Decision Trees, Diagnosis, Differential, DNA Mutational Analysis - methods, DNA Mutational Analysis - standards, Female, Frontotemporal Lobar Degeneration - diagnosis, Frontotemporal Lobar Degeneration - genetics, Frontotemporal Lobar Degeneration - physiopathology, Genetic Predisposition to Disease - genetics, Genetic Testing - economics, Genetic Testing - methods, Genetic Testing - standards, Humans, Male, Middle Aged, Mutation - genetics, Nerve Tissue Proteins - genetics, Phenotype