Details

Autor(en) / Beteiligte

• Zabrodskiĭ, P F
• Svistunov, A A
• Lim, V G
• Grishin, V A
• Kuz'min, A V
• Smurov, A V

Titel

Pharmacological correction of Th1 and Th2 lymphocyte activity and cytokine profile in ethanol intoxicated rats

Ist Teil von

• Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 2010-11, Vol.73 (11), p.19

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• It was established in experiments on noninbred rats that their ethanol intoxication (13 days; total dose, 2.6 LD50) significantly reduces the concentration of blood cytokines IFNgamma, IL-2, IL-4, IL-10, increases the concentration of IL-6, suppresses the immune responses, and reduces the interrelation IFNgamma/IL-4 in comparison to the control, which testifies to the greater damage of Th1 cells in comparison to Th2 lymphocytes. The immunomodulator polyoxidonium administered for four days at a daily dose of 700 microg/kg fully restores the cellular and humoral immune responses and the synthesis of cytokines IFNgamma, IL-2, and IL-4 and partly restores the production of IL-10.