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Brain glucose utilization and transport and cortical function in chronic vs. acute hypoglycemia
Ist Teil von
American journal of physiology: endocrinology and metabolism, 1990-11, Vol.259 (5), p.E729-E735
Ort / Verlag
United States
Erscheinungsjahr
1990
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
D. A. Pelligrino, L. J. Segil and R. F. Albrecht
Department of Anesthesiology, Michael Reese Hospital and Medical Center, Chicago, Illinois 60616.
We compared regional brain capillary permeability-surface area products for
glucose transfer (PSin), cerebral glucose utilization (rCMRGlc) rates, and
brain tissue glucose levels (GlCbr) in N2O-sedated, paralyzed, and
artificially ventilated rats during normoglycemia (NG), insulin-induced
acute hypoglycemia (AH), or chronic hypoglycemia (CH) [hypoglycemic plasma
glucose (Glcp) = 2.2-2.3 mumol/ml]. In addition, a comparative assessment
of brain function in AH vs. CH was performed employing somatosensory-evoked
response (SSER) technology. A double-label (3H and 14C) 2-deoxy-D-glucose
method was used for the simultaneous assessment of PSin and rCMRGlc.
Compared with normoglycemic controls, AH resulted in significant 40-50%
reductions in rCMRGlc in 10 of 11 regions analyzed (cerebellum unchanged).
In CH vs. AH, significantly higher values for rCMRGlc, Glcbr/Glcp ratios,
and PSin were seen in 8, 8, and 5 regions, respectively. No differences in
rCMRGlc were observed when comparing CH vs. NG groups. Furthermore, CH rats
were able to sustain normal SSER at levels of hypoglycemia (1.5 mumol/ml)
that, when imposed acutely, resulted in attenuated SSER. Thus CH is
associated with an enhanced blood-brain glucose transport capacity in many
(but not all) brain regions. This in turn increases rCMRGlc and improves
the general cerebral function compared with that seen during AH.