Details

Autor(en) / Beteiligte

• He, Ai-Li
• Bai, Ju
• Huang, Chen
• Zhang, Wang-Gang
• Yang, Juan
• Wang, Jian-Li
• Meng, Xin
• Tian, Wei

Titel

Preliminarily screening of serum characteristic markers in acute myeloid leukemia and clinical significance

Ist Teil von

• Zhongguo shi yan xue ye xue za zhi, 2010-10, Vol.18 (5), p.1132

Ort / Verlag

China

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• This study was purposed to preliminarily screen characteristic tumor markers of acute myeloid leukemia (AML) and to investigate the serum proteomics characteristics of patients with AML and their significance in pathogenesis. 14 patients with AML and 28 healthy controls were enrolled in this study. The serum protein components were captured by weak cation exchange nanometer magnetic beads, the protein mass-spectra of all samples were detected by Autoflex II matrix-assisted laser desorption/ionization time of flight mass spectrometer, and the detection data were analyzed by means of CliprotoolsTM2.2 software, then the differential protein molecules were screened and the diagnostic model was established. Sera of 7 AML patients and 14 healthy controls were selected to verify the established model by using blind test. The results indicated that about 69 protein peaks could be detected within the range of 0.7-10 kD in protein spectra of serum samples from AML patients and controls. Compared with healthy controls,