Details

Autor(en) / Beteiligte

• Shastri, K A
• Logue, G L
• Zeid, M Y
• Behrens, A N
• Lenahan, E J
• Haar, J G

Titel

Acquired factor VIII inhibitor with squamous cell cancer of the epiglottis

Ist Teil von

• Archives of otolaryngology--head & neck surgery, 1990-03, Vol.116 (3), p.350

Ort / Verlag

United States

Erscheinungsjahr

1990

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A 73-year-old woman developed an acquired factor VIII inhibitor in association with squamous cell carcinoma of the epiglottis. The inhibitor was an IgG antibody that reacted with factor VIII in vitro and in vivo. Intravenous gamma-globulin therapy was successful in reducing the inhibitor so that curative surgery could be undertaken. With surgical resection of the tumor the inhibitor did not recur. The relevance of this type of coagulation disorder to the surgical management of the patient's head and neck cancer is discussed.