Details

Autor(en) / Beteiligte

• Stumhofer, Jason S
• Tait, Elia D
• Quinn, 3rd, William J
• Hosken, Nancy
• Spudy, Björn
• Goenka, Radhika
• Fielding, Ceri A
• O'Hara, Aisling C
• Chen, Yi
• Jones, Michael L
• Saris, Christiaan J M
• Rose-John, Stefan
• Cua, Daniel J
• Jones, Simon A
• Elloso, Merle M
• Grötzinger, Joachim
• Cancro, Michael P
• Levin, Steven D
• Hunter, Christopher A

Titel

A role for IL-27p28 as an antagonist of gp130-mediated signaling

Ist Teil von

• Nature immunology, 2010-12, Vol.11 (12), p.1119-1126

Ort / Verlag

United States

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique functions. Here we show that IL-27p28, independently of EBI3, antagonized cytokine signaling through gp130 and IL-6-mediated production of IL-17 and IL-10. Similarly, the ability to generate antibody responses was dependent on the activity of gp130-signaling cytokines. Mice transgenic for expression of IL-27p28 showed a substantial defect in the formation of germinal centers and antibody production. Thus, IL-27p28, as a natural antagonist of gp130-mediated signaling, may be useful as a therapeutic for managing inflammation mediated by cytokines that signal through gp130.