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The design, annotation, and application of a kinase-targeted library
Ist Teil von
Methods in molecular biology (Clifton, N.J.), 2011, Vol.685, p.279
Ort / Verlag
United States
Erscheinungsjahr
2011
Quelle
MEDLINE
Beschreibungen/Notizen
We present here a workflow for designing a kinase-targeted library (KTL) with the goal of capturing known kinase inhibitor chemical space. We validated our design retrospectively using recent, high-throughput screening data and found significant enrichment of kinase inhibitor hits while retaining majority of the active kinase inhibitor series. To further assist kinase projects in triaging KTL screen hits, we also developed a methodology to systematically annotate known kinase inhibitors in the KTL with regard to their binding modes.