Science signaling, 2010-10, Vol.3 (145), p.ra77
2010
Details
- Autor(en) / Beteiligte
- Titel
- Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels
- Ist Teil von
- Science signaling, 2010-10, Vol.3 (145), p.ra77
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The Rho family of small guanosine triphosphatases (Rho GTPases: RhoA, Cdc42, and Rac1) regulates many aspects of cell behavior, including actin dynamics and cell migration. The generation of calcium ion (Ca(2+)) microdomains is critical in promoting cell migration because they control the localized activity of Rho GTPases. We identified receptor-activated TRPC5 and TRPC6 (transient receptor potential canonical type 5 and 6) channels as antagonistic regulators of actin remodeling and cell motility in fibroblasts and kidney podocytes. We show that TRPC5 is in a molecular complex with Rac1, whereas TRPC6 is in a molecular complex with RhoA. TRPC5-mediated Ca(2+) influx induces Rac1 activation, thereby promoting cell migration, whereas TRPC6-mediated Ca(2+) influx increases RhoA activity, thereby inhibiting cell migration. Our data unveil antagonistic Ca(2+) influx pathways as a conserved signaling mechanism for the integrated regulation of cell migration.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1937-9145DOI: 10.1126/scisignal.2001200Titel-ID: cdi_pubmed_primary_20978238
- Format
- –
- Schlagworte
- Actins - genetics, Actins - metabolism, Animals, Calcium - metabolism, Calcium Signaling - physiology, Cell Movement - physiology, HEK293 Cells, Humans, Mice, Neuropeptides - genetics, Neuropeptides - metabolism, rac GTP-Binding Proteins - genetics, rac GTP-Binding Proteins - metabolism, rac1 GTP-Binding Protein, rho GTP-Binding Proteins - genetics, rho GTP-Binding Proteins - metabolism, TRPC Cation Channels - genetics, TRPC Cation Channels - metabolism