Details

Autor(en) / Beteiligte

• Hansen, N
• Finzel, M
• Block, F

Titel

Antiepileptic drug-induced encephalopathy

Ist Teil von

• Fortschritte der Neurologie-Psychiatrie, 2010-10, Vol.78 (10), p.590

Ort / Verlag

Germany

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• The clinical features of an antiepileptic drug-induced encephalopathy (ADE) are confusion, reduction of vigilance, neurological deficits or an increase of the seizure frequency. In the electroencephalogram a general slowing or epileptic discharges are found. Characteristic are non-toxic blood levels of the antiepileptic drugs. So far an ADE was reported under phenytoin, carbamazepine or valproatic acid (valproate) therapy. More seldom, an ADE has been described after the intake of vigabatrine, lamotrigine und topiramate. Potential pathogenic mechanisms of AED are hyperammonemia, intrinsic effects on cerebral receptors, drug interactions, hepatic enzyme interactions, metabolic reasons or paradoxical proconvulsive effects of antiepileptic drugs. The medicamentous therapy consists of an immediate discontinuation of the antiepileptic drug.