Details

Autor(en) / Beteiligte

• Deng, Min
• Li, Ming-Hui
• Liu, Shun-Ai
• Liu, Feng
• Sang, Yan
• Song, Shu-Jing
• Zang, Shu-Feng
• Guan, Xiao-Ping
• Yao, Xie
• Wu, Xiao-Ping
• Cheng, Jun
• Xu, Dao-Zhen

Titel

Studies about the level of CD4+ CD25+ regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV infection

Ist Teil von

• Zhonghua shi yan he lin chuang bing du xue za ji, 2010-02, Vol.24 (1), p.21

Ort / Verlag

China

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the level of CD4+ CD25+ Foxp3+ regulatory T cells and observe relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV infection. CD4+ CD25+ Foxp3+ and CD4+ CD25+ CD127low Treg in peripheral blood from 34 patients of immune tolerance stage, 26 patients of immune clearance stage and 31 patients of non-active status were quantitatively analyzed by flow cytometry. Immune tolerance group presented a higher fraction of CD4+ CD25+ Foxp3+ and CD4+ CD25+ CD127low Treg than non-active group in chronic HBV infection (Z = -2.693, P = 0.007 and t = 3.251, P = 0.002), and HBV positive group also presented a higher fraction than non-active group (t = 2.266, P = 0.026 and t = 3.208, P = 0.002), But ALT normal group is similar to ALT abnormal group (P > 0.05). In this study, the relation between expression of CD127low and Foxp3+ from CD4+ CD25+ regulatory T cells was observed, and CD4+ CD25+ CD127low Treg presented a higher fraction than CD4+ CD25+ Foxp3+ Treg. Peripheral Treg in HBV a