Details

Autor(en) / Beteiligte

• Øie, Erik
• Sandberg, Wiggo J.
• Ahmed, Mohammad Shakil
• Yndestad, Arne
• Lærum, Ole Didrik
• Attramadal, Håvard
• Aukrust, Pål
• Eiken, Hans Geir

Titel

Activation of Notch signaling in cardiomyocytes during post-infarction remodeling

Ist Teil von

• Scandinavian cardiovascular journal : SCJ, 2010-12, Vol.44 (6), p.359-366

Ort / Verlag

England: Informa Healthcare

Erscheinungsjahr

2010

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Abstract Objective. Notch signaling is crucial for cell-to-cell interaction during cardiovascular development and may influence differentiation, proliferation, and apoptotic events. We investigated whether Notch signaling is activated during myocardial remodeling in heart failure (HF). Design. Myocardial gene expression and localization of Notch receptors (Notch1-4) and ligands (Jagged1-2, and Delta-like (Dll)-1 and 4) were investigated in rats with HF after induction of myocardial infarction and in humans with HF. Results. All Notch receptors and ligands investigated and Notch intracellular domain (NICD) were present in rat and human myocardial tissue and in cardiomyocytes with differences in their relative expression levels and altered expression levels in failing vs. non-failing myocardium. In isolated rat cardiomyocytes, Notch3 and Notch4 appeared to be the major Notch receptors, and Notch3 and Notch4 mRNA levels and NICD-3 and -4 in cardiomyocytes were upregulated in chronic HF (p < 0.05), indicating increased Notch3 and Notch4 signaling. Conclusion. The Notch signaling system is present in the cardiomyocytes and activated in HF, indicating a role of Notch signaling during myocardial remodeling in HF.