Details

Autor(en) / Beteiligte

• Martins-de-Souza, Daniel
• Harris, Laura W
• Guest, Paul C
• Bahn, Sabine

Titel

The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics

Ist Teil von

• Antioxidants & redox signaling, 2011-10, Vol.15 (7), p.2067

Ort / Verlag

United States

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Schizophrenia is a psychiatric illness that affects approximately 30 million people worldwide. Converging lines of evidence suggest that mitochondrial function may be compromised in this disorder, and this can lead to perturbations in calcium buffering, oxidative phosphorylation, increased production of reactive oxygen species, and apoptotic factors, which can, in turn, affect neuronal processes such as neurotransmitter synthesis and synaptic plasticity. Proteomics studies in brain and peripheral tissues of schizophrenia patients have provided considerable evidence and identified biomarker fingerprints corresponding to such pathways. Here we review the results of these studies with a focus on the biomarker pattern depicting alterations in energy metabolism and oxidative stress in this debilitating illness.