Details

Autor(en) / Beteiligte

• Anuchin, A M
• Goncharenko, A V
• Galon, I V
• Demidenok, O I
• Kudykina, Iu K
• Moĭsenovich, M M
• Muliukin, A L
• Kaprel'iants, A S

Titel

The model of resting forms of mycobacteria for testing of drugs for latent forms of tuberculosis

Ist Teil von

• Prikladnaja biohimija i mikrobiologija, 2010-05, Vol.46 (3), p.308

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• The new model of obtaining of ovoid resting forms Mycobacterium smegmatis, which are morphologically different from vegetative (rod-like) cells, was developed. Ovoid forms were characterized by a drastically decreased level of metabolic activity, an increased stability to heat processing and antibiotics action, and also by prolonged (more than 2 months) storage time preserving colony-forming ability. Obtained resting forms of mycobacteria may be used in test-systems for checking efficiency of new medical agents against latent forms of tuberculosis and determination of role of these of those genes in entering rest state.