Details

Autor(en) / Beteiligte

• Wu, Chin-Lee
• Jordan, Kate W
• Ratai, Eva M
• Sheng, Jinhua
• Adkins, Christen B
• Defeo, Elita M
• Jenkins, Bruce G
• Ying, Leslie
• McDougal, W Scott
• Cheng, Leo L

Titel

Metabolomic imaging for human prostate cancer detection

Ist Teil von

• Science translational medicine, 2010-01, Vol.2 (16), p.16ra8

Ort / Verlag

United States

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• As current radiological approaches cannot accurately localize prostate cancer in vivo, biopsies are conducted at random within prostates for patients at risk for prostate cancer, leading to high false-negative rates. Metabolomic imaging can map cancer-specific biomolecular profile values onto anatomical structures to direct biopsy. In this preliminary study, we evaluated five whole prostates removed during prostatectomy from biopsy-proven cancer patients on a 7-tesla human whole-body magnetic resonance scanner. Localized, multi-cross-sectional, multivoxel magnetic resonance spectra were used to construct a malignancy index based on prostate cancer metabolomic profiles obtained from previous intact tissue analyses with a 14-tesla spectrometer. This calculated malignancy index is linearly correlated with lesion size and demonstrates a 93 to 97% overall accuracy for detecting the presence of prostate cancer lesions, suggesting the potential clinical utility of this approach.