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Expression and significance of P53 and P21 in nasal NK/T-cell lymphoma
Ist Teil von
Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban, 2010-01, Vol.41 (1), p.132
Ort / Verlag
China
Erscheinungsjahr
2010
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
To investigate the significance of P53 and P21 expressions in nasal NK/T-cell lymphoma (NKTL) and their relationships with the clinical stage, prognosis, proliferation and apoptosis of tumor cells.
The clinicopathologic and follow-up data was collected from 62 patients with NKTL proven by pathological examination. Sixty-two cases of NKTL were examined for P53, P21 and Ki67 proteins with tissue microarray technique and immunohistochemistry. TUNEL method was used to detect apoptosis (apoptosis index, AD). The proliferation index (PI) was determined by the expression of Ki67 proteins.
The positive rates of P53 and P21 protein expression in NKTL were 79.03% and 58.06% respectively. The positive rates of P53 in Ann Arbor stage I, II, III and lV NKTL were 69.57%, 75.00%, 86.67% and 100.00% respectively, while those of P21 were 47.83%, 56.25%, 60.00% and 87.50%. With the progression of tumor, the positive expression rates of P53 and P21 proteins gradually increased. And there were significant differences statistical