Details

Autor(en) / Beteiligte

• Dolgova, E V
• Rogachev, V A
• Nikolin, V P
• Popova, N A
• Likhacheva, A S
• Aliamkina, E A
• Sebeleva, T E
• Chernykh, E R
• Gel'fgat, E L
• Bogachev, S S
• Shudrov, M A

Titel

Leukocyte stimulation by DNA fragments shored up protamine in cyclophosphamide-induced leukopoiesis in mice

Ist Teil von

• Voprosy onkologij, 2009, Vol.55 (6), p.761

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Our study showed that protamine (80% w/w to DNA) effectively protected its molecules from degradation by native nucleases of the mammalian blood serum. Exogenous DNA bound to protamine effectively stimulated restoration of cyclophosphamide-induced leukopoiesis in mice. It is suggested that the phenomenon was due to repair processes taking place in hemopoietic stem cells damaged by a cross-linking cytostatic drug such as cyclophosphamide. DNA dosage may be reduced and the original DNA fragment size maintained by DNA binding to protamine. As a result, it might involve longer DNA fragments into repair processes of homologous recombination and eventually increase the cell's chances of getting rid of extensive damage.