Details

Autor(en) / Beteiligte

• Danilenko, E D
• Sysoeva, G M
• Ustimenko, S Iu
• Samukov, V V
• Kostanian, I A
• Masycheva, V I

Titel

Investigation of antitumor activity of the hexamer fraction of HLDF-6 peptide as a differentiation factor in hemoblastoma-bearing mice

Ist Teil von

• Voprosy onkologij, 2009, Vol.55 (6), p.757

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• A study of antitumor properties of HLDF-6 was carried out in DBA/2 mice with transplantable ascites lympholeukemia P-388 as well as in tumor cell culture. Immunomodulating characteristics were evaluated. Five-fold administration of HLDF-6 peptide to tumor-bearing mice inhibited tumor growth thus extending survival. As a result metabolic activity decreased which was followed by longer survival of lympholeukemia P-388 cells and enhanced cytological effect of peritoneal macrophages on tumor cells of the same strain.