Zhonghua shi yan he lin chuang bing du xue za ji, 2009-08, Vol.23 (4), p.261
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Frequency, distribution of CD4+, CD8+ T cells and expression of CD38 in gastric mucosa of HIV infections
- Ist Teil von
- Zhonghua shi yan he lin chuang bing du xue za ji, 2009-08, Vol.23 (4), p.261
- Ort / Verlag
- China
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the frequencies and distribution of CD4+ T cells and CD8+ T cells as well as the changes of immune activation in gastric mucosa of HIV-infected individuals. 42 HIV-infected individuals were recruited into this investigation, and 36 patients had definite diagnosis of clinical stage. Biopsy of gastric mucosal tissues was performed by fiberoptic gastroscope including 10 normal people as a control group. Then, immunohistochemistry was used to detect expression of CD4, CD8 and CD38 in gastric mucosa, and the distinctions among three groups were analyzed with LEICA Qwin image analysis system. (1) Compared with asymptomatic HIV carriers and control group, CD4 T cells remarkably decreased in the gastric mucosa of AIDS patients (P < 0.01). In gastric mucosa of asymptomatic HIV carriers, there were still some CD4+ T cells in lymphoid follicles and stroma where CD4+ T cells were unevenly distributed, the frequency of CD4+ T cells was not significantly different between asymptomatic HIV carriers and contro
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1003-9279Titel-ID: cdi_pubmed_primary_20108768
- Format
- –
- Schlagworte
- ADP-ribosyl Cyclase 1 - genetics, ADP-ribosyl Cyclase 1 - immunology, Adult, CD4-Positive T-Lymphocytes - cytology, CD4-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - cytology, CD8-Positive T-Lymphocytes - immunology, Female, Gastric Mucosa - immunology, Gene Expression, HIV Infections - genetics, HIV Infections - immunology, HIV-1 - immunology, Humans, Lymphocyte Count, Male, Middle Aged