Zhonghua gan zang bing za zhi, 2009-12, Vol.17 (12), p.930
2009
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- Autor(en) / Beteiligte
- Titel
- A prospective study of the relationship between serum hepatitis B virus DNA and the risk of primary liver cancer
- Ist Teil von
- Zhonghua gan zang bing za zhi, 2009-12, Vol.17 (12), p.930
- Ort / Verlag
- China
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To determine the relationship between the serum hepatitis B virus (HBV) DNA and the risk of primary liver cancer (PLC). Farmers aged 30 to 55 years in Long An county were recruited in this study Blood samples were collected and the sera were tested for HBsAg using Enzyme-Linked ImmunoSorbent Assay (ELISA), and the HBsAg-positive sera were further tested for viral DNA using nested polymerase chain reaction (nPCR). The study subjects were divided into three groups. The first group was positive for both HBsAg and HBV DNA. The second group was positive for HBsAg but negative for HBV DNA. Age-, sex-, residence-matched HBsAg negative controls for group 1 and group 2 were enrolled in the third group. The cohort was followed up for four years. The positive rate of HBsAg in these farmers was 14.52% (3975/27,379), and the HBV DNA positive rate in HBsAg positive subjects was 40.35% (1604/3975). The total PLC incidence rate in Group 1 and 2 was 672.45 /100,000 person-years (PY), significantly higher than that in Group3 (
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1007-3418Titel-ID: cdi_pubmed_primary_20038336
- Format
- –
- Schlagworte
- Adult, Carcinoma, Hepatocellular - epidemiology, Carcinoma, Hepatocellular - virology, China - epidemiology, DNA, Viral - blood, Female, Follow-Up Studies, Hepatitis B - complications, Hepatitis B Surface Antigens - blood, Hepatitis B virus - genetics, Hepatitis B virus - isolation & purification, Humans, Liver Neoplasms - epidemiology, Liver Neoplasms - virology, Male, Middle Aged, Polymerase Chain Reaction, Prospective Studies, Risk Factors, Viral Load, Young Adult