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Sympatholytic response to stimulation of superior laryngeal nerve in rats
Ist Teil von
American journal of physiology. Regulatory, integrative and comparative physiology, 1991-02, Vol.260 (2), p.290-R297
Ort / Verlag
United States
Erscheinungsjahr
1991
Quelle
MEDLINE
Beschreibungen/Notizen
D. H. Huangfu and P. G. Guyenet
Department of Pharmacology, University of Virginia, Charlottesville 22908.
The central pathway mediating a sympatholytic response to stimulation of
the superior laryngeal nerve (SLN) was studied in halothane-anesthetized,
paralyzed rats. Single-pulse stimulation of SLN inhibited lumbar
sympathetic nerve discharge (LSND) with onset latency of 113 +/- 1.7 ms.
LSND inhibition was markedly attenuated by bilateral microinjection of
kynurenic acid (Kyn, glutamate receptor antagonist, 4.5 nmol/side) into the
caudal ventrolateral medulla (CVL) or by bilateral administration of
bicuculline methiodide (Bic; gamma-aminobutyric acid-receptor antagonist,
225 pmol/side) into the rostral ventrolateral medulla (RVL). In 13 of 14
cases, the baroreceptor reflex was also severely reduced. Injections of Bic
or Kyn elsewhere in the medullary reticular formation were ineffective.
Single-pulse stimulation of SLN inhibited 19 of 26 RVL reticulospinal
barosensitive cells (onset latency 46 +/- 1.4 ms). This inhibition was
attenuated (from 92 +/- 6 to 14 +/- 12%) by iontophoretic application of
Bic (n = 7), which also reduced the cells' inhibitory response to aortic
coarctation. The remaining seven barosensitive neurons were unaffected by
SLN stimulation. In conclusion, the sympathetic baroreflex and the
sympathoinhibitory response to SLN stimulation appear to be mediated by
similar medullary pathways.