Details

Autor(en) / Beteiligte

• Densmore, A
• Vachon, M
• Xu, D-X
• Janz, S
• Ma, R
• Li, Y-H
• Lopinski, G
• Delâge, A
• Lapointe, J
• Luebbert, C C
• Liu, Q Y
• Cheben, P
• Schmid, J H

Titel

Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection

Ist Teil von

• Optics letters, 2009-12, Vol.34 (23), p.3598

Ort / Verlag

United States

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• We demonstrate a silicon photonic wire waveguide biosensor array chip for the simultaneous monitoring of different molecular binding reactions. The chip is compatible with automated commercial spotting tools and contains a monolithically integrated microfluidic channel for sample delivery. Each array sensor element is a 1.8-mm-long spiral waveguide folded within a 130 microm diameter spot and is incorporated in a balanced Mach-Zehnder interferometer with a near temperature independent response. The sensors are arranged in a 400 microm spacing grid pattern and are addressed through cascaded 1x2 optical power splitters using light from a single input fiber. We demonstrate the real-time monitoring of antibody-antigen reactions using complementary and mismatched immunoglobulin G receptor-analyte pairs and bovine serum albumin. The measured level of detection for each sensor element corresponds to a surface coverage of less than 0.3 pg/mm(2).