Details

Autor(en) / Beteiligte

• Gelot, Antoinette
• Villapol, S.
• Billette de Villemeur, Thierry
• Renolleau, Sylvain
• Charriaut-Marlangue, Christiane

Titel

Astrocytic Demise in the Developing Rat and Human Brain after Hypoxic-Ischemic Damage

Ist Teil von

• Developmental neuroscience, 2009-01, Vol.31 (5), p.459-470

Ort / Verlag

Basel, Switzerland: S. Karger AG

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• In order to approach the physiopathological mechanism underlying the selective susceptibility of the immature brain to hypoxia-ischemia (HI), we have compared the lesions experimentally induced in postnatal day 7 rats using a model of neonatal stroke with those occurring in human fetal and neonatal brains. We first observed that gray and white matter lesions demonstrated a similar organization (core with cell loss and/or cavity and penumbra) and evolutionary pattern between experimental and human HI lesions. We then observed that, in the intermediate white matter, GFAP- and vimentin-positive astrocytes exhibited clasmatodendrosis and represent a major cell population involved in cell death in human brains (56.3 and 67.9%, respectively). In rat brains, GFAP- and TUNEL-positive astrocytes were also highly vulnerable, increasing between 6 (31%) and 72 (58%) hours after ischemia. Together, these results indicate that astroglial dysfunction may play a critical role in determining the progress and outcome of acute hypoxic-ischemic injury particularly in the developing brain.