Details

Autor(en) / Beteiligte

• Dessailly, Benoît H
• Reid, Adam J
• Yeats, Corin
• Lees, Jonathan G
• Cuff, Alison
• Orengo, Christine A

Titel

The evolution of protein functions and networks: a family-centric approach

Ist Teil von

• Biochemical Society transactions, 2009-08, Vol.37 (Pt 4), p.745-750

Ort / Verlag

England

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• The study of superfamilies of protein domains using a combination of structure, sequence and function data provides insights into deep evolutionary history. In the present paper, analyses of functional diversity within such superfamilies as defined in the CATH-Gene3D resource are described. These analyses focus on structure-function relationships in very large and diverse superfamilies, and on the evolution of domain superfamily members in protein-protein complexes.