Details

Autor(en) / Beteiligte

• Marchioli, Roberto
• Levantesi, Giacomo
• Silletta, Maria G
• Barlera, Simona
• Bernardinangeli, Marino
• Carbonieri, Emanuele
• Cosmi, Francesco
• Franzosi, Maria G
• Latini, Roberto
• Lucci, Donata
• Maggioni, Aldo Pietro
• Moretti, Luciano
• Nicolosi, Gian L
• Porcu, Maurizio
• Rossi, Maria G
• Tognoni, Gianni
• Tavazzi, Luigi

Titel

Effect of n-3 polyunsaturated fatty acids and rosuvastatin in patients with heart failure: results of the GISSI-HF trial

Ist Teil von

• Expert review of cardiovascular therapy, 2009-07, Vol.7 (7), p.735

Ort / Verlag

England

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Epidemiological, experimental studies and post hoc analyses of randomized trials suggested that n-3 polyunsaturated fatty acids (PUFA) and statins could be beneficial in chronic heart failure. Two double-blind, placebo-controlled, randomized clinical trials investigated the efficacy and safety of n-3 PUFA 1 g daily (R1) and rosuvastatin 10 mg daily (R2) in patients with heart failure. In total, 6975 and 4574 patients were randomized in R1 and R2, respectively; the main reason for excluding patients from R2 being the open-label administration of statin treatment. Primary end points were death, and death or admission to hospital for cardiovascular reasons. n-3 PUFA, but not rosuvastatin, significantly decreased the two coprimary end points: 56 and 44 patients needed to be treated with n-3 PUFA for a median duration of 3.9 years to avoid one death or one cumulative event. Both drugs were safe and were tolerated. A simple and safe treatment with n-3 PUFA provides a beneficial advantage in patients with heart failure in a context of usual care.