Drug metabolism letters, 2007-12, Vol.1 (4), p.254
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites
- Ist Teil von
- Drug metabolism letters, 2007-12, Vol.1 (4), p.254
- Ort / Verlag
- United Arab Emirates
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1874-0758Titel-ID: cdi_pubmed_primary_19356051
- Format
- –
- Schlagworte
- Acute Lung Injury - drug therapy, Acute Lung Injury - physiopathology, Anti-Inflammatory Agents - isolation & purification, Anti-Inflammatory Agents - pharmacology, Cell Line, Endothelial Cells - drug effects, Endothelial Cells - metabolism, Gene Expression Regulation, Humans, Intercellular Adhesion Molecule-1 - metabolism, Models, Biological, Neutrophil Infiltration - drug effects, Nostoc - chemistry, Nostoc - metabolism, Pulmonary Alveoli - drug effects, Pulmonary Alveoli - physiopathology, Wound Healing - drug effects