Details

Autor(en) / Beteiligte

• Yu, Xiao-Yun
• Zhong, Yuan
• Niu, Yu-Hong
• Qu, Chun-Qing
• Li, Ge-Xin
• Lü, Xiu-Qiang
• Sun, Gui-Fan
• Jin, Ya-Ping

Titel

Effect of glutathione and sodium selenite on the metabolism of arsenic in mice exposed to arsenic through drinking water

Ist Teil von

• Zhōnghuá yùfáng-yīxué zázhì, 2008-09, Vol.42 (9), p.636

Ort / Verlag

China

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• To explore the effect of glutathione (GSH) and sodium selenite on the metabolism of arsenic in the liver, kidney and blood of mice exposed to iAsIII through drinking water. The mice were randomly divided into control, arsenic, GSH and sodium selenite group, respectively. And each group had eight mice and the mice were exposed to 50 mg/L arsenite by drinking water for 4 weeks. Mice were intraperitoneally injected with GSH (600 mg/kg) and sodium selenite (1 mg/kg) for seven days from the beginning of the fourth week. At the end of the fourth week, liver, kidney and blood were sampled to assess the concentrations of inorganic arsenic (iAs), monomethylarsenic acid (MMA), dimethylarsenic acid (DMA) by hydride generation trapping by ultra-hypothermia coupled with atomic absorption spectrometry. The liver DMA (233.76 +/- 60.63 ng/g) concentration in GSH group was significantly higher than the arsenic group (218.36 +/- 42.71 ng/g). The concentration of DMA (88.52 +/- 30.86 ng/g) and total arsenic (TAs) (162.32 +/- 49