Zhōnghuá zhŏngliú zázhì, 2008-12, Vol.30 (12), p.944
2008
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- Autor(en) / Beteiligte
- Titel
- Docetaxel and capecitabine combination chemotherapy for patients with anthracycline-resistant metastatic breast cancer
- Ist Teil von
- Zhōnghuá zhŏngliú zázhì, 2008-12, Vol.30 (12), p.944
- Ort / Verlag
- China
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To evaluate the efficacy and safety of docetaxel and capecitabine combination chemotherapy (DC regimen) for patients with anthracycline-resistant metastatic breast cancer. Thirty-two patients with anthracycline-resistant metastatic breast cancer were treated with a docetaxel and capecitabine combination regimen. All patients received oral administration of capecitabine at a dose of 1250 mg/m(2) twice daily, within 30 min after meal on D1 to D14, and intravenous infusion of docetaxel at a dose of 75 mg/m(2) on D1. The regimen was repeated every 3 weeks. A total of 126 cycles of DC regimen were administered in the 32 cases, with a median of 4 cycles. The overall response rate was 46.9%. Among the 32 patients, there were complete response in 1, partial response in 14, stable disease in 11 and progressive disease in 6 cases. The median time to progression (TTP) was 5.6 months. The one-year survival rate was 56.3%. The effective cases in different metastatic organs were: 8 cases in the lung, 6 cases in the liver,
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0253-3766Titel-ID: cdi_pubmed_primary_19174000
- Format
- –
- Schlagworte
- Adult, Aged, Anthracyclines - pharmacology, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Breast Neoplasms - drug therapy, Breast Neoplasms - pathology, Capecitabine, Deoxycytidine - administration & dosage, Deoxycytidine - adverse effects, Deoxycytidine - analogs & derivatives, Disease Progression, Drug Resistance, Neoplasm, Female, Fluorouracil - administration & dosage, Fluorouracil - adverse effects, Fluorouracil - analogs & derivatives, Humans, Lung Neoplasms - drug therapy, Lung Neoplasms - secondary, Lymphatic Metastasis, Middle Aged, Remission Induction, Survival Rate, Taxoids - administration & dosage, Taxoids - adverse effects