Details

Autor(en) / Beteiligte

• Zuber, Chantal
• Mitteregger, Gerda
• Pace, Claudia
• Zerr, Inga
• Kretzschmar, Hans A.
• Weiss, Stefan

Titel

Anti-LRP/LR Antibody W3 Hampers Peripheral PrPSc Propagation in Scrapie Infected Mice

Ist Teil von

• Prion, 2007-07, Vol.1 (3), p.207-212

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• We identified the 37/67kDa laminin receptor (LRP/LR) as a cell surface receptor for the cellular prion protein (PrPc) and the infectious prion protein (PrPSc). Recently, we showed that anti-LRP/LR antibody W3 cured scrapie infected N2a cells. Here, we demonstrate that W3 delivered by passive immunotransfer into C57BL/6 mice reduced the PrPSc content in the spleen significantly by 66%, demonstrating an impairment of the peripheral PrPSc propagation. In addition, we observed a 1.8 fold increase in survival of anti-LRP/LR antibody W3 treated mice (mean survival of 31 days) compared to preimmune serum treated control animals (mean survival of 17 days). We conclude that the significant effect of anti-LRP/LR antibody W3 on the reduction of peripheral PrPSc propagation might be due to the blockage of the prion receptor LRP/LR which is required, as previously shown in vitro, for PrPSc propagation in vivo.