Details

Autor(en) / Beteiligte

• Chang, In Ho
• Ahn, Seung Hyun
• Han, June Hyun
• Kim, Tae-Hyoung
• Kim, Young Sun
• Myung, Soon Chul

Titel

The Clinical Significance in Healthy Men of the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration

Ist Teil von

• The Journal of urology, 2009-02, Vol.181 (2), p.567-573

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose We investigated the association between body mass index and the concentration of tumor markers including carcinoembryonic antigen, α-fetoprotein, the carbohydrate antigen 19-9 and prostate specific antigen, as well as the association between body mass index changes and tumor marker concentration changes in a population of healthy men. Materials and Methods We evaluated data on 8,776 men screened for tumor markers (carcinoembryonic antigen, α-fetoprotein, carbohydrate antigen 19-9 and prostate specific antigen) at least 3 times annually during an annual examination from 2001 to 2007. We assessed the tumor marker test findings for a trend in the age, alanine aminotransferase and creatinine adjusted tumor marker concentration by body mass index. We used multivariate regression analysis to determine whether a change in body mass index was associated with a tumor marker concentration change over time using calculated tumor markers, body mass index, creatinine and alanine aminotransferase concentration change per year. Results After adjusting for age, creatinine and alanine aminotransferase a higher body mass index was associated with lower prostate specific antigen (p for trend <0.001), carcinoembryonic antigen (p for trend <0.001) and carbohydrate antigen 19-9 (p for trend <0.001). On multivariate regression analysis each 1 kg/m2 of body mass index gain per year was associated with a −0.011 ng/ml change in prostate specific antigen concentration, a –0.030 ng/ml change in carcinoembryonic antigen concentration and a −0.192 IU/ml change in carbohydrate antigen 19-9 concentration per year. Conclusions In this cohort of healthy men hemodilution from increased plasma volume may be responsible for the observed decreased tumor marker concentration in men with a higher body mass index. In addition, an increase in body mass index may predict a lower tumor marker concentration in an individual.