Zhonghua yi xue yi chuan xue za zhi, 2008-10, Vol.25 (5), p.542
2008
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- Autor(en) / Beteiligte
- Titel
- DC-SIGNR polymorphisms and its association with HIV-1 infection
- Ist Teil von
- Zhonghua yi xue yi chuan xue za zhi, 2008-10, Vol.25 (5), p.542
- Ort / Verlag
- China
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To explore the association of the polymorphism of homologue of dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN related, DC-SIGNR) gene with the susceptibility to HIV-1 infection. The distribution of the DC-SIGNR variants in the tandem repeat region and their association with HIV-1 infection in a cohort composed of 345 HIV-1 seropositive and 468 high-risk HIV-1 seronegative individuals was examined. There are 14 genotypes and 5 alleles in the DC-SIGNR repeat regions in the cohort. Although the most common DC-SIGNR allele among Chinese Han population and the Caucasian population is 7, it was found in a higher frequency in the Chinese than in Caucasians (67.1% vs.46.0%, P<0.01). HIV-1 seropositive individuals had a lower frequency of the genotype 7/7 than the high-risk seronegative individuals (38.55% vs. 48.29%, P=0.0057), but a higher frequency of genotype 9/5 (4.35% vs. 1.07%, P=0.0029). These results suggest that the tandem-repeat polymorphisms of the DC-SIGNR
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1003-9406Titel-ID: cdi_pubmed_primary_18841568
- Format
- –
- Schlagworte
- Adult, Alleles, Cell Adhesion Molecules - genetics, Cohort Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, HIV Infections - genetics, HIV Infections - transmission, HIV Infections - virology, HIV-1, Humans, Lectins, C-Type - genetics, Male, Polymorphism, Genetic, Receptors, Cell Surface - genetics