Journal of the American College of Nutrition, 2008-04, Vol.27 (2), p.356-366
2008
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- Autor(en) / Beteiligte
- Titel
- Novel Resistant Maltodextrin Alters Gastrointestinal Tolerance Factors, Fecal Characteristics, and Fecal Microbiota in Healthy Adult Humans
- Ist Teil von
- Journal of the American College of Nutrition, 2008-04, Vol.27 (2), p.356-366
- Ort / Verlag
- New York, NY: American College of Nutrition
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- OBJECTIVE: Resistant maltodextrin has been shown to increase fecal bulk by resisting digestion and being partially fermented by colonic bacteria to short-chain fatty acids (SCFA). The objective of this experiment was to determine potential prebiotic effects, gastrointestinal tolerance, and fecal characteristics of free-living humans fed a novel resistant maltodextrin or a normal maltodextrin control. METHODS: Subjects (n = 38) were enrolled in a randomized, double-blind study where they were assigned to one of three daily treatments: 15 g maltodextrin; 7.5 g maltodextrin plus 7.5 g resistant maltodextrin (Fibersol-2®; Matsutani Chemical Company, Hyogo, Japan); and 15 g resistant maltodextrin. The experiment lasted 7 wk and consisted of a 2 wk baseline period, a 3 wk treatment period, and a 2 wk washout period. During wk 3 to 5 (treatment period), subjects consumed their assigned treatments. RESULTS: Resistant maltodextrin supplementation tended to increase (p = 0.12) fecal Bifidobacterium populations during the treatment period, altered (p < 0.05) bacterial populations from baseline to treatment, and resulted in very minor effects in gastrointestinal tolerance. There was a shift (p < 0.05) in molar proportions of SCFA towards butyrate, the preferred energy substrate of colonocytes. CONCLUSION: Resistant maltodextrin supplementation was well tolerated, resulted in favorable fermentation characteristics in the large bowel, and also resulted in a change in bacterial populations.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0731-5724eISSN: 1541-1087DOI: 10.1080/07315724.2008.10719712Titel-ID: cdi_pubmed_primary_18689571
- Format
- –
- Schlagworte
- Adult, adults, Ammonia - metabolism, available carbohydrate, Bifidobacterium, Bifidobacterium - genetics, Bifidobacterium - growth & development, Biological and medical sciences, CFU = colony forming unit, Clostridium perfringens - genetics, Clostridium perfringens - growth & development, colon, DGGE = denaturing gradient gel electrophoresis, dietary fiber, digestion, digestive tract, DNA, Bacterial - chemistry, DNA, Bacterial - genetics, Double-Blind Method, Electrophoresis, Polyacrylamide Gel, Fatty Acids, Volatile - metabolism, fecal microbiota, feces, Feces - chemistry, Feces - microbiology, Feeding. Feeding behavior, Female, fermentable carbohydrate, fermentation, Fundamental and applied biological sciences. Psychology, Gastrointestinal Tract - drug effects, Gastrointestinal Tract - microbiology, Gastrointestinal Tract - physiology, human subjects, Humans, intestinal microorganisms, Lactobacillus - genetics, Lactobacillus - growth & development, Male, maltodextrins, PCR = polymerase chain reaction, Polymerase Chain Reaction, Polysaccharides - administration & dosage, Polysaccharides - chemistry, prebiotic, prebiotics, qPCR = quantitative real-time polymerase chain reaction, RNA, Ribosomal, 16S - chemistry, RNA, Ribosomal, 16S - genetics, SCFA = short-chain fatty acids, short chain fatty acids, Vertebrates: anatomy and physiology, studies on body, several organs or systems