Zhonghua nan ke xue, 2008-07, Vol.14 (7), p.590
2008
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- Autor(en) / Beteiligte
- Titel
- Estrogens affect Sertoli cells and the blood-testis barrier in pubertal rats
- Ist Teil von
- Zhonghua nan ke xue, 2008-07, Vol.14 (7), p.590
- Ort / Verlag
- China
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the correlation of exogenous estrogens with the expression of FasL in Sertoli cells and the blood-testis barrier during the differentiation and maturation period of Sertoli cells, and to discuss the related factors that influence the blood-testis barrier of pubertal rats. Super-physiological doses of exogenous estrogenic compounds (diethylstilbestrol and estradiol) were administered to pubertal Sprague-Dawley rats in vitro and in vivo, the FasL expression in the Sertoli cells of the rats detected by immunohistochemistry and Western blot, and the changes in the blood-testis barrier observed with the electron microscope. After the exposure to exogenous estrogens, the FasL expression was markedly up-regulated in the immature Sertoli cells (P < 0.05) as well as in the Sertoli cell membrane and the blood-testis barrier of the epithelium. The tracer lanthanum passed through the blood-testis barrier and reached the whole layer of the epithelium at 18 days. Super-physiological dose of exogenous estroge
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1009-3591Titel-ID: cdi_pubmed_primary_18686377
- Format
- –
- Schlagworte
- Animals, Animals, Newborn, Apoptosis - drug effects, Blood-Testis Barrier - drug effects, Blood-Testis Barrier - metabolism, Estrogens - pharmacology, Fas Ligand Protein - biosynthesis, Male, Models, Animal, Rats, Rats, Sprague-Dawley, Sertoli Cells - cytology, Sertoli Cells - drug effects, Sertoli Cells - metabolism