Details

Autor(en) / Beteiligte

• Pilarczyk, Małgorzata
• Pawłowska, Małgorzata
• Jendryczka, Ewa

Titel

Efficacy of retherapy of chronic hepatitis C in children--own observation

Ist Teil von

• Przegląd epidemiologiczny, 2008, Vol.62 (1), p.101

Ort / Verlag

Poland

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of the study was an assessment of retherapy in children with chronic hepatitis C. Investigations were performed in 41 children divided on 2 groups (A and B). Children from group A were treated firstly with IFN monotherapy during 6 months and as retherapy they administered combined therapy with IFN alpha and ribavirin during 12 months. Patients from group B were firstly treated with combined IFN alpha and ribavirin therapy during 12 months and as retherapy with pegylated IFN and ribavirin. Sustained viral response achieved 44% of children (58% from group A and 33% from group B). ALT activity normalization was observed in 46% of treated children (53% from group A and 45% from group B). Prevalence of relapses in group A and B was 14% and 37% respectively. Among children who responded on treatment, baseline ALT activity was statistically significant higher in group A (p<0.05). The age of children from this group was statistically significant lower in comparison with children from group B (p<0.02). Mean leukocytes count after 3 months of treatment was statistically significant lower in children treated with pegylated IFN and ribavirin (p<0.02). Retherapy of chronic hepatitis in children was effective and well tolerated. The high frequency of relapses seems to be a point of extending of retherapy.