Details

Autor(en) / Beteiligte

• Maslov, Konstantin
• Zhang, Hao F
• Hu, Song
• Wang, Lihong V

Titel

Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries

Ist Teil von

• Optics letters, 2008-05, Vol.33 (9), p.929

Ort / Verlag

United States

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Capillaries, the smallest blood vessels, are the distal end of the vasculature where oxygen and nutrients are exchanged between blood and tissue. Hence, noninvasive imaging of capillaries and function in vivo has long been desired as a window to studying fundamental physiology, such as neurovascular coupling. Existing imaging modalities cannot provide the required sensitivity and spatial resolution. We present in vivo imaging of the microvasculature including single capillaries in mice using optical-resolution photoacoustic microscopy (OR-PAM) developed in our laboratory. OR-PAM provides a lateral resolution of 5 microm and an imaging depth >0.7 mm.