Details

Autor(en) / Beteiligte

• Kong, Hong-bin
• Li, You-sheng

Titel

Distribution of hepatitis B virus genotypes and its clinical significance

Ist Teil von

• Zhonghua shi yan he lin chuang bing du xue za ji, 2007-12, Vol.21 (4), p.372

Ort / Verlag

China

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• To study the distribution of hepatitis B virus genotypes in Handan area and clarify the genotype-related difference in clinic. Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to detect the HBV genotypes in 108 HBV-infected patients from Handan area. The clinical significance of HBV genotype was analyzed in combination with the values of HBV DNA and ALT. Among the 108 HBV-infected patients, the proportion of genotype B and C was 6.5 percent and 93.5 percent, respectively. Genotype distribution showed no significant difference between male and female patients. ALT and AST levels were higher in genotype C group than those in genotype B group. HBV genotype C is predominant in chronic hepatitis B patients in Handan area. The positive rates of HBeAg and HBV DNA levels were higher in genotype C group than those in genotype B group. Genotype C was associated with the development of severe liver disease as compared to genotype B.