Details

Autor(en) / Beteiligte

• Bagaeva, V V
• Avrov, K A
• Reshetnikova, G F

Titel

E-cadherin affects MAP activation by growth factors stimulation in human carcinoma cells

Ist Teil von

• T͡S︡itologii͡a, 2007, Vol.49 (12), p.1017

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Met and EGF receptor (EGFR) activation is correlated with dissociation of cell-cell adhesion and with increase in mobility of cancer cells. E-cadherin is a major protein of adhesion junctions. Using different approaches we have shown that EGF receptors intracellular localization depends of E-cadherin function. It was found that EGFR localized on the membrane in HT-29 cells which formed mature cell-cell contacts. Moreover, EGFR was colocalized with E-cadherin at the site of cell-cell adhesion in Triton-insoluble fraction. EGFR was accumulated preliminary in cytosol in E-cadherin negative HBL-100 cells. Study of signal transduction mediated by EGF and HGF in cells with different state of cell adhesion demonstrated that E-cadherin could affect ERK-signal-duration. Our preliminary studies proposed that mislocalization of Met and EGFR in E-cadherin negative cells altered receptors downstream signaling.