Details

Autor(en) / Beteiligte

• Kim, N.Y. (Konkuk University, Seoul, Republic of Korea)
• Kim, J.H. (Konkuk University, Seoul, Republic of Korea)
• Lee, Y.H. (Konkuk University, Seoul, Republic of Korea)
• Lee, E.J. (Konkuk University, Seoul, Republic of Korea)
• Kim, J.Y. (Konkuk University, Seoul, Republic of Korea)
• Lim, Y.H. (Konkuk University, Seoul, Republic of Korea)
• Chong, Y.H. (Konkuk University, Seoul, Republic of Korea)
• Ahn, J.H. (Konkuk University, Seoul, Republic of Korea), E-mail: jhahn@konkuk.ac.kr

Titel

O-Methylation of Flavonoids Using DnrK Based on Molecular Docking

Ist Teil von

• Journal of microbiology and biotechnology, 2007-12, Vol.17 (12), p.1991-1995

Ort / Verlag

Seoul: Korean Society for Applied Microbiology

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• O-Methylation is a common substitution reaction found in microbes as well as in mammalians. Some of the O-methyltransferases (OMTs) have broad substrate specificity and could be used to methylate various compounds. DnrK from Streptomyces peucetius encodes an anthracycline 4-O-methyltransferase, which uses carminomycin as a substrate, and its crystal structure has been determined. Molecular docking experiments with DnrK using various flavonoids were successfully conducted, and some of the flavonoids such as apigenin and genistein were predicted to serve as substrates.