Details

Autor(en) / Beteiligte

• Shin, S S
• Pasechnikov, A D
• Gelmanova, I Y
• Peremitin, G G
• Strelis, A K
• Mishustin, S
• Barnashov, A
• Karpeichik, Y
• Andreev, Y G
• Golubchikova, V T
• Tonkel, T P
• Yanova, G V
• Yedilbayev, A
• Rich, M L
• Mukherjee, J S
• Furin, J J
• Atwood, S
• Farmer, P E
• Keshavjee, S

Titel

Adverse reactions among patients being treated for MDR-TB in Tomsk, Russia

Ist Teil von

• The international journal of tuberculosis and lung disease, 2007-12, Vol.11 (12), p.1314

Ort / Verlag

France

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Treatment of multidrug-resistant tuberculosis (MDR-TB) is challenging because of the toxicity of second-line medications. Little is known about whether adverse events impact treatment outcome. We conducted a retrospective case series of 244 MDR-TB patients enrolled in Tomsk between 10 September 2000 and 10 September 2002. Adverse reactions were determined by laboratory data and/or clinical criteria. A multiple logistic regression model was performed to determine whether the occurrence of adverse reactions was associated with poor treatment outcome. In this cohort, 76.0% were cured, 6.6% failed, 4.9% died and 11.5% defaulted. Adverse events were observed in 73.3% of patients, occurring in 74.8% of patients who were adherent (taking at least 80% of prescribed doses) and 59.1% of non-adherent individuals (P = 0.11). The impact of adverse events on outcome was modified by non-adherence; among adherent patients, the occurrence of any adverse reaction was associated with treatment cure (adjusted odds ratio 3.24, 95% confidence interval 1.56-6.70). Adverse reactions occurred frequently in MDR-TB patients in Tomsk, Russia, but did not negatively impact treatment outcome. The occurrence of adverse reactions among adherent patients was associated with treatment cure.