Details

Autor(en) / Beteiligte

• Wang, Xiao-Fei
• Yuan, Shuang-Long
• Jiang, Li
• Zhang, Xiao-Li
• Li, Shu-Fan
• Guo, Yun
• Wu, Chun-Ling
• Chen, Juan-Juan

Titel

Changes of serum BAFF and IL-21 levels in patients with systemic lupus erythematosus and their clinical significance

Ist Teil von

• Xi bao yu fen zi mian yi xue za zhi, 2007-11, Vol.23 (11), p.1041

Ort / Verlag

China

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the changes of serum BAFF and IL-21 levels in the patients with systemic lupus erythematosus (SLE) and explore their clinical significance. The serum levels of BAFF and IL-21 were detected by enzyme-linked immunosorbent assay (ELISA). The levels of serum BAFF and IL-21 in the patients with SLE were obviously higher than those in healthy control group. The BAFF level in the group of lupus nephritis (LN) with renal biopsy increased with pathologic aggravation and the IL-21 level in II, III, IV LN also increased, with the most obviously change in the type IV. The levels of BAFF and IL-21 obviously increased in SLE patients with Sjogren's syndrome (SS), but the levels of BAFF and IL-21 obviously tended to decrease in the patients after glucocorticosteroid treatment for a week, with the most significant decrease in BAFF. The changes of BAFF and IL-21 were related to major immune indexes in the patients with SLE. There was positive correlation between BAFF and IL-21 in IV LN. The levels of serum BAFF