Details

Autor(en) / Beteiligte

• O'Fallon, Brendan D
• Adler, Frederick R
• Proulx, Stephen R

Titel

Quasi-species evolution in subdivided populations favours maximally deleterious mutations

Ist Teil von

• Proceedings of the Royal Society. B, Biological sciences, 2007-12, Vol.274 (1629), p.3159

Ort / Verlag

England

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Most models of quasi-species evolution predict that populations will evolve to occupy areas of sequence space with the greatest concentration of neutral sequences, thus minimizing the deleterious mutation rate and creating mutationally 'robust' genomes. In contrast, empirical studies of the principal model of quasi-species evolution, RNA viruses, suggest that the effects of deleterious mutations are more severe than in similar DNA-based microbes. We demonstrate that populations divided into discrete patches connected by dispersal may favour genotypes where the deleterious effect of non-neutral mutations is maximized. This effect is especially strong in the absence of back mutation and when the amount of time spent in hosts prior to dispersal is intermediate. Our results indicate that RNA viruses that produce acute infections initiated by a small number of virions are expected to evolve fragile genetic architectures when compared with other RNA viruses.