Details

Autor(en) / Beteiligte

• de Vries, Annemarie C
• Besselink, Marc G.H
• Buskens, Erik
• Ridwan, Ben U
• Schipper, Maria
• van Erpecum, Karel J
• Gooszen, Hein G

Titel

Randomized Controlled Trials of Antibiotic Prophylaxis in Severe Acute Pancreatitis: Relationship between Methodological Quality and Outcome

Ist Teil von

• Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2007-10, Vol.7 (5-6), p.531-538

Ort / Verlag

Basel, Switzerland: Elsevier B.V

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Aim: To evaluate the methodological quality of randomized controlled trials (RCTs) of systemic antibiotic prophylaxis in severe acute pancreatitis in relation to outcome. Methods: The MEDLINE, EMBASE and Cochrane databases were searched for RCTs that studied the effectiveness of systemic antibiotic prophylaxis in severe acute pancreatitis. A meta-analysis was performed with a random effects model. Methodological quality was quantified by a previously published scoring system (range 0–17 points). Results: Six studies, with a total of 397 participants, obtained a methodological score of at least 5 points and were included. Systemic antibiotic prophylaxis had no significant effect on infection of pancreatic necrosis (absolute risk reduction (ARR) 0.055; 95% Cl -0.084 to 0.194) and mortality (ARR 0.058, 95% Cl -0.017 to 0.134). Spearman correlation showed an inverse association between methodological quality and ARR for mortality (correlation coefficient -0.841, p = 0.036). Conclusions: The inverse relationship between methodological quality and impact of antibiotic prophylaxis on mortality emphasizes the importance of high-quality RCTs. At present, adequate evidence for the routine use of antibiotic prophylaxis in severe acute pancreatitis is lacking.