Ai zheng = Aizheng = Chinese journal of cancer, 2007-08, Vol.26 (8), p.914
2007
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- Autor(en) / Beteiligte
- Titel
- Efficacy and toxicity of intravenous busulfan-based conditioning before allogeneic peripheral blood stem cell transplantation for leukemia
- Ist Teil von
- Ai zheng = Aizheng = Chinese journal of cancer, 2007-08, Vol.26 (8), p.914
- Ort / Verlag
- China
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Busulfan (Bu) is commonly used as a component of conditioning regimens for hematopoietic stem cell transplantation. Erratic gastrointestinal absorption as a result of oral administration of Bu not only affects the efficacy, but also increases the risk of toxicity. This study was to analyze the efficacy and toxicity of intravenous Bu and cyclophosphamide (Cy) conditioning before allogeneic peripheral blood stem cell transplantation (allo-PBSCT) for leukemia. Fifteen leukemia patients received intravenous Bu/Cy conditioning before allo-PBSCT, while 20 patients received oral Bu/Cy conditioning. The responses and adverse events of the 2 groups were assessed. All 15 patients in intravenous Bu/Cy group had hematopoietic engraftment. The median time of engraftment was 12 (9-15) days for neutrophils and 15 (11-24) days for platelets. Of the 15 patients, 6 (40.0%) developed acute graft-versus-host disease (aGVHD), including 4 cases of grade I-II aGVHD and 2 cases of grade III-IV aGVHD; during conditioning, 7 (46.6%) h
- Sprache
- Chinesisch
- Identifikatoren
- Titel-ID: cdi_pubmed_primary_17697559
- Format
- –
- Schlagworte
- Adolescent, Adult, Busulfan - administration & dosage, Busulfan - adverse effects, Busulfan - therapeutic use, Cyclophosphamide - administration & dosage, Cyclophosphamide - adverse effects, Cyclophosphamide - therapeutic use, Female, Follow-Up Studies, Graft vs Host Disease - prevention & control, Humans, Immunosuppressive Agents - administration & dosage, Immunosuppressive Agents - adverse effects, Immunosuppressive Agents - therapeutic use, Injections, Intravenous, Leukemia - drug therapy, Leukemia - therapy, Male, Middle Aged, Mucositis - chemically induced, Peripheral Blood Stem Cell Transplantation, Transplantation Conditioning, Transplantation, Homologous, Vomiting - chemically induced, Young Adult